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首页> 中文期刊> 《畜牧与生物技术杂志：英文版》 >Novel SNPs in IL-17F and IL-17A genes associated with somatic cell count in Chinese Holstein and Inner-Mongolia Sanhe cattle

Novel SNPs in IL-17F and IL-17A genes associated with somatic cell count in Chinese Holstein and Inner-Mongolia Sanhe cattle

         
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摘要

Background: Bovine mastitis is the most common and costly disease of lactating cattle worldwide. Apart from milk somatic cell count(SCC) and somatic cell score(SCS), serum cytokines such as interleukin-17(IL-17) and interleukin-4(IL-4) may also be potential indicators for bovine mastitis. The present study was designed to investigate the effects of single nucleotide polymorphisms(SNPs) in bovine IL-17 F and IL-17 A genes on SCC, SCS and serum cytokines in Chinese Holstein and Inner-Mongolia Sanhe cattle, and to compare the m RNA expression variations of the cows with different genotypes.Results: A total of 464 lactating cows(337 Holstein and 127 Inner-Mongolia Sanhe cattle) were screened for SNPs identification and the data were analyzed using fixed effects of herd, parity, season and year of calving by general linear model procedure. The results revealed that SNP g.24392436 C > T in IL-17 F and SNP g.24345410 A > G in IL-17 A showed significant effects on SCC and IL-4 in Holstein(n = 337) and on IL-17 and IL-4 in Sanhe cattle(n = 127). The homozygous GG genotype of SNP g.24345410 A > G had significantly higher m RNA expression compared with the heterozygous AG genotype.Conclusions: The results indicate that IL-17 F and IL-17 A could be powerful candidate genes of mastitis resistance and the significant SNPs might be useful genetic markers against mastitis in both dairy and dual purpose cattle.

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  • 来源
    《畜牧与生物技术杂志：英文版》 |2017年第002期|P.361-369|共9页
  • 作者

    Tahir Usman; Yachun Wang; Chao Liu; Yanghua He; Xiao Wang; Yichun Dong; Hongjun Wu; Airong Liu; Ying Yu;

  • 作者单位

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

    [1]Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture of China, National Engineering Laboratory for Animal Breeding,College of Animal Science and Technology, China Agricultural University,Beijing 100193, People＇s Republic of China. [2]College of Veterinary Sciences and Animal Husbandry, Abdul Wali Khan University Mardan,Mardan 23200,Pakistan. [3]Xieerltala Breeding Farm, Hailaer 021012, Inner Mongolia, China. [4]Agricultural and Animal Husbandry Administration Bureau, Hailaer 021000,Inner Mongolia, China.;

  • 原文格式 PDF
  • 正文语种 CHI
  • 中图分类 S823.91;
  • 关键词

    中国荷斯坦牛 SNPs 相关基因 体细胞数 三河市 内蒙古 白细胞介素-17 单核苷酸多态性;

    机译：中国荷斯坦牛 SNPs 相关基因 体细胞数 三河市 内蒙古 白细胞介素-17 单核苷酸多态性;
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