质谱检测泰乐菌素的方法研究进展

摘要

广泛应用于医学和兽医学领域的泰乐菌素具有中谱抗菌功能和动物生长促进作用，在各种介质中的污染状况和环境行为备受关注，质谱检测技术由于具有高效、稳定、高灵敏度等特点，成为泰乐菌素检测的主要手段。重点介绍2011年以来不同基质中泰乐菌素的样品前处理方法，以及LC－ESI－MS／MS、LDTD－APCI－MS／MS、LC－SALDI－MS 、LC－Q－Orbitrap等各种质谱检测技术的研究进展，以期为同类研究提供一定的参考。%Tylosin has a spectrum of antibacterial function and animal growth promoting effect, which is harm to humans and the environment, and arouses widespread attention.The mass spectrometry has become the major method for the determination of tylosin due to high efficiency , stability and sensitivity.In this research, we mainly introduced the sample pretreatment methods of tylosin in different substrates since 2011, as well as the research progresses of various mass spectrometry detection technologies, such as LC-ESI-MS/MS, LDTD-APCI-MS/MS, LC-SALDI-MS and LC-Q-Orbitrap.This research provides certain references for the further studies in similar works.