胰腺实性假乳头状瘤的临床病理特征及外科治疗

摘要

目的 探讨胰腺实性假乳头状瘤(solm pseudopapillary tumor of the pancreas,SFTP)的临床病理特征和外科治疗方法.方法 对2003年11月至2010年6月间24例经术后病理学确诊的SPTP病人的临床资料进行回顾性分析.结果 本组中男性7例,女性17例,女性占70.83%,女性中位年龄为25.3岁.肿瘤病灶位于胰头部5例,胰颈体部8例,胰体尾部11例,全部病例无特征性临床表现.术前血清淀粉酶和消化肿瘤标记物检查均为阴性.24例均获手术治疗,无围手术期死亡病例,术后胰漏3例,术后随访期间未见复发、转移现象.结论 胰腺实性假乳头状瘤多见于青年女性,属具有恶性潜能的胰腺肿瘤.外科手术切除可获得良好的临床治疗效果.%Objective To investigate the clinic-pathological features of solid pseudopapillary tumor of the pancreas(SPTP) and evaluate the efficacy of surgical treatment. Methods From Nov.2003 to Jun. 2010,24 cases of SPTP confirmed pathologically were subjected to surgical resection in our centre. The clinical data were analyzed retrospectively. Results Among 24 cases, there were 7males, 17 females(70. 83 ％ ), and the mean age for females was 25. 3 years old. The neoplasm was found in the pancreatic head in 5 cases, in body-neck in 8 and in the body-tail in 11, with no specificity in clinical manifestation. None of the patients had positive serum amylase and digestive tumor markers preoperatively. Twenty-four cases were subjected to surgical resection with no peri-operative death,and postoperative pancreatic fistula occurred in 3 cases. No evidence of local recurrence or metastasis was found during the follow-up period after complete resection of the primary tumor. Conclusion SPTP is a rare pancreatic neoplasm with malignant potentiality, and mainly affected young women.Surgical resection for SPTP can offer a good long-term survival for patients.