目的：观察西咪替丁联合培菲康（双歧杆菌三联活菌散）防治早产儿坏死性小肠结肠炎的临床疗效。方法：选取100例早产儿坏死性小肠结肠炎患儿，随机分为两组，每组50例。对照组单纯服用培菲康治疗，试验组给予西咪替丁与培菲康联合治疗，对比两组临床疗效及不良反应。结果：试验组总有效率为96％，明显优于对照组的78％，差异具有统计学意义（ P﹤0.05）。两组均未见明显不良反应。结论：西咪替丁联合培菲康方案治疗早产儿坏死性小肠结肠炎具有较好的防治效果，安全性高，值得推广应用。%Objective To observe the clinical efficacy of cimetidine combined with Bifico( triple viable Bifidobacterium bulk)prevention of necrotizing enterocolitis in preterm children. Method 100 cases of patients with preterm children necrotizing enterocolitis were randomly divided into two groups,50 cases of each group. The control group received Bifico treatment,the experimental group received cimetidine and Bifico combination therapy. Treatment effects of the two groups were observed and statistically analyzed. Results Total efficiency rate of exper-imental group was 96%,which was significantly higher than 78% of the control group,there was statistical significance(P﹤0. 05). The two groups had no significant adverse reactions. Conclusion The effect of cimetidine combined with Bifico in the treatment of necrotizing enteroco-litis in preterm children is better,high safety,it is worthy of popularization and application.
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