Objective To investigate the serum concentration of NO and related indexes of obesity with Phlegm-dampness constitution(OPD),compared with obesity with no Phlegm-dampness constitution(ONPD)and Metabolic Syn-drome(MS),so as to reveal the endothelial function of OPD,which can provide guidance for taking precautions against MS and Cardio-cerebrovascular Complications from the perspective of Phlegm-dampness constitution. Methods Four groups of volunteers were chose in this study:33 cases of obesity with Phlegm-dampness constitution(OPD),31 cases of obesity with NO Phlegm-dampness constitution(ONPD),24 cases of metabolic syndrome group(MS),and 25cases of the normal balanced constitution group(N). In each group,we detect obesity related indices such as BMI,WC,F% ,and MS related indices such as DBP,SBP,FPG,TG,HDL-C,LDL-C and TC. We detect NO related indices such as NOS,iNOS, insulin and ralculated the Insulin Resistance Indexes HOMA-IR. Results Compared with the group N,obesity and MS related indices were significantly higher or lower in the group MS(P < 0. 05 or P < 0. 01). In the group ONPD,there were no significant differences in other indices(P >0. 05). In the group OPD,Obesity related indices were significantly higher(P <0. 01),SBP,DBP,TG were significantly higher(P < 0. 05),HDL-C,and HDL-C were significantly lower (P <0. 01),but there were no significant differences with FPG,LDL-C,TC. In group OPD ,Obesity related indices were similar(P >0. 05),and DBP,TG were significantly higher,and other MS indices were similar(P >0. 05)than the group ONPD. As for NO,compared with N,there were no significant differences in ONPD ,but significantly higher in OPD and MS(P <0. 05 or P <0. 01). As for NOS,compared with N,there were no significant differences in ONPD and MS ,but significantly higher in OPD(P <0. 05). As for iNOS,compared with N,there were no significant differences in ONPD , but significantly higher in OPD and MS(P < 0. 05). There were also significant differences between OPD and ONPD (P <0. 05). As for IR,compared with N,there were no statistical significance in ONPD(P >0. 05). Compared with ON-PD,there were also significant differences in OPD and MS(P < 0. 05). Conclusion The persons with OPD have had vascular endothelial dysfunction even not reaching the clinical diagnostic criteria of MS,with the significant differences of NO,iNOS,IR. Obesity whether with Phlegm-dampness constitution is the key risk factor for endothelial dysfunction. So,we should pay close attention to the endothelial function of persons with Phlegm-dampness constitution and give early intervention and treatment,taking advantage of Traditional Chinese Medicine“Preventive Treatment of Disease”,which has important significance for preventing MS and cardio-cerebrovascular complications.%目的：检测肥胖痰湿体质人群血清一氧化氮自由基（NO）及其相关指标，并与肥胖非痰湿及代谢综合征患者比较，揭示肥胖痰湿体质人群内皮功能状态。方法选取符合标准的平和体质组（N）25例，肥胖痰湿组（OPD）33例，肥胖非痰湿组（ONPD）31例，代谢综合征组（MS）26例，进行 BMI、WC、体脂率等肥胖相关指标检测及代谢相关指标检测。用硝酸还原酶法测定血清 NO 含量，用化学比色法测定 iNOS、NOS 含量，用电化学发光免疫法检测血清胰岛素水平，并采用稳态模式评估法计算胰岛素抵抗值（HOMA-IR）。结果1）与 N 组相比，各组肥胖程度和代谢指标均有不同程度的升高或降低（P <0.05或 P <0.01），除 MS 组外其余均不够构成 MS 诊断。ONPD 与 OPD 相比，肥胖程度无明显变化（P >0.05），但 DBP、TG 有显著增高（P <0.05）。2）与 N 组相比，NO 含量 ONPD 无明显变化，OPD 及 MS 组有显著降低（P <0.05，P <0.01）。NOS 含量 OPD 组有显著升高（P <0.05），其余2组无变化，MS 组与 OPD 组相比亦有显著降低（P <0.05）。iNOS 在 ONPD 组无明显变化，OPD 和 MS 组有显著升高（P <0.05）。OPD 与 ONPD 相比亦有显著升高（P <0.05）。3）MS 和 OPD 组水平显著增高（P <0.01）， ONPD 组有一定程度的升高，但无统计学意义（P >0.05）。OPD 和 MS 组较 ONPD 组亦明显升高（P <0.05）。结论肥胖痰湿体质人群在构成 MS 诊断前即出现内皮功能紊乱征兆，是否具备痰湿体质是肥胖者内皮功能紊乱危险度的关键因素。早关注痰湿人群内皮功能状态并早干预，对预防代谢综合征及心脑血管并发症具有重要意义。
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