通络熄风方加减辨治老年糖尿病合并急性脑卒中

摘要

Objective To investigate the clinical effect of Tongluo Xifeng Decoction in treating senile diabetes combined with acute stroke,in order to improve the curative effect.Methods 106 patients of senile diabetes combined with acute stroke in December 2009-2015 were selected as subjects and divided into two groups.Control group (53 cases) was given conventional western medicine treatment and observation group (53 cases) was added Tongluo Xifeng Decoction.Then,we have to observe the changes of relevant indicators after treatment.Results In terms of efficacy,the basic cure rate of control group is 18.87％ and total efficient is 79.25％.The basic cure rate of the observation group is 35.85％ and the total efficiency is 94.34％.The observation group was significantly better than the control group (P＜0.05).In Fib,D-D,FBG,HBAIC,the two groups after treatment were significantly lower than before treatment (P＜0.05).After treatment,the observation group was significantly better than the control group(P＜0.05);The control group before and after treatment ofPt,ET-1,TXB2 and NO have no difference (P＞0.05),and the observation group after treatment of ET-1 and TXB2 decreased significantly and NO increased significantly (P＜0.05).After the treatment,the observation group of ET-1,TXB2 and NO significantly are better than the control group (P＜0.05).Conclusion Tongluo Xifeng Decoction can improve vascular endothelial function in senile diabetes combined with acute stroke.%目的 探讨通络熄风方加减辨治老年糖尿病合并急性脑卒中临床效果,以期提高疗效.方法 选取2009年12月-2015年12月106例老年糖尿病合并急性脑卒中患者作为研究对象,分成2组,对照组53例,予常规西医治疗,观察组53例,加用通络熄风方治疗,观察治疗后在相关指标变化情况.结果 疗效上,对照组基本痊愈率18.87％、总有效率79.25％,观察组基本痊愈率35.85％、总有效率94.34％,观察组显著优于对照组(P＜0.05);在Fib、D-D、FBG、HbAIC上2组治疗后较治疗前均显著下降(P＜0.05),治疗后观察组以上指标显著优于对照组(P＜0.05);对照组治疗前后PT、ET-1、TXB2、NO无统计学意义(P＞0.05),而观察组治疗后ET-1、TXB2显著下降,NO显著升高(P＜0.05),治疗后观察组ET-1、TXB2、NO显著优于对照组(P＜0.05).结论:运用通络熄风方治疗消渴中风病后,患者在Fib、D-D、FBG、HbAIC上显著下降,说明中医药能改善凝血功能,促使血糖下降更快,改善血管内皮功能.