白塞补泻颗粒治疗白塞病

摘要

目的 观察白塞补泻颗粒治疗白塞病的临床疗效.方法 选取40例确诊为白塞病的患者,随机分为治疗组和对照组.治疗组给予白塞补泻颗粒治疗,早、中、晚餐后半小时各服6 g,对照组给予沙利度胺100 mg,1次/d,晚睡前口服.2组均连续治疗2个月.2个月后2组观察症状、血沉、C反应蛋白和不良反应等.结果 治疗组患者的临床总有效率(90％)明显高于对照组(75％),且治疗组患者ESR(18.10±3.96)mm·h-1、CRP(9.03±3.33)mg·L-1明显优于对照组(23.10±4.60)mm·h-1、(12.29±3.79)mg·L-1,2组比较差异有统计学意义(P<0.05);治疗组患者的复发率也较对照组低(P<0.05).结论 白塞补泻颗粒治疗白塞病临床疗效优于沙利度胺,可能与其抗炎、抗感染、调节免疫功能、改善微循环与血液流变学等作用有关.%Objective To observe the effect of Baisai Buxie granules on Behcet's disease.Methods 40 patients with Behcet's disease were randomly divided into treatment group (n=20) and control group (n=20). The treatment group was given Baisai Buxie granules treatment, early, half an hour after dinner to take the 6g, the control group treated with 100mg, 1 time /d, oral before night sleep. The 2 groups were treated continuously for 2 months. 2 months later, the 2 groups were compared to observe symptoms, erythrocyte sedimentation, C reactive protein, and adverse reactions.Results The treatment group patients with the total effective rate (90％) was significantly higher than the control group (75％), and the patients in the treatment group ESR (18.10 + 3.96) mm, H-1, CRP (9.03±3.33) Mg - L-1 was significantly better than the control group (23.10±4.60) mm, H-1 (12.29±3.79) Mg - L-1. The 2 groups were significantly different (P<0.05), recurrence rate of the patients in the treatment group is lower than the control group (P<0.05).Conclusion Effect of Baisai Buxie granules in BD is better than thalidomide, may be related to its anti-infl ammatory anti-infection, immune function, microcirculation and hemorheology improvement.