2型糖尿病患者丙型肝炎病毒感染率

摘要

Objective To clarify the role of hepatitis C virus (HCV) infection in the pathogenesis of diabetes mellitus (DM). Methods The highly sensitive third generation detection kit was used to test anti-HCV in 533 patients with type 2 DM(group A) , 285 healthy people(group B), and 862 non-diabetic patients who had no defined chronic hepatic diseases (group C). Statistical analysis was performed by the Student's t-test for continuous variables and Fisher s exact test for categorical data Results There were no significant differences in positive rates of anti-HCV among groups of A, B and C (1. 31% , 0. 70% and 0. 58%) (P>0. 05). HCV infection in diabetic patients was related to the age, DM duration, and history of surgical procedures (P<0. 01). There was no significant difference in the changes of liver function between the patients with type 2 DM combined with HCV infection and those with HCV infection alone. Conclusion HCV infection plays little role in the pathogenesis of type 2 DM in Chinese patients and it is not necessary to routinely test HCV in DM.%目的 研究丙型肝炎病毒(HCV)感染与糖尿病发生的关系.方法 用高度灵敏的第3代抗-HCV检测试剂,测定533例2型糖尿病患者(A组)、285例普通体检人群(B组)和862例无慢性肝病的非糖尿病患者(C组)血清抗HCV,比较抗体阳性率差异,并分析HCV易患因素.结果 A组抗-HCV阳性7例,阳性率1.31%,B组和C组分别为2例(0.70%)和5例(0.58%),组间比较,无统计学差异(P>0.05).糖尿病患者HCV感染与年龄、病程和手术史有关(P<0.01).糖尿病合并HCV感染者与单纯HCV感染者肝功能改变差异无统计学意义.结论 我国HCV感染在糖尿病发生中的作用较小,对糖尿病患者无需常规检测抗-HCV.