肺癌患者血浆腺苷酸含量的变化

摘要

Objective To investigate the changes of energy metabolism in the patients with lung cancer(LC). Methods ATP, ADP and AMP in plasma were determined by HPLC method in 15 LC patients(group A) and 13 control subjects(group B). Results Compared with group B, plasma content of ATP was decreased in group A [(0.292 ± 0.023) mmol/L vs. (0. 405 ± 0. 083 ) mmol/L] (P＜0. 01), but that of ADP was elevated [ (0.141 ± 0.014 ) mmol/L vs. (0. 130 ± 0. 020) mmol/L] ( P＜0. 05),while plasma AMP was not significantly changed. Conclusion Compared to healthy people,plasma content of ATP is decreased,but that of ADP is elevated in the patients with LC,which may be related with the change in energy metabolism of LC patients.%目的 了解肺癌病理过程中的能量代谢变化.方法 采用高效液相法测定非小细胞性肺癌患者15例(A组)和健康体检者13例(B组)血浆腺苷酸(ATP、ADP、AMP)的含量.结果 与B组比较,A组患者血浆中ATP含量下降[(0.292±0.023)mmol/L vs.(0.405±0.083)mmol/L](P<0.01),ADP升高[(0.141±0.014)mmol/L VS.(0.130±0.020)mmol/L](P<0.05),AMP含量无明显变化.结论 肺癌患者血浆ATP含量较正常人为低,ADP含量升高,可能与肺癌患者体内能量代谢发生改变有关.