G蛋白β3亚单位的基因多态性与美托洛尔降压疗效的关系

摘要

Objective To investigate the correlation of G protein β3 subunit gene C825T polymorphism and efficacy of metoproiol in treating essential hypertension(EH). Methods Fifty-two elder patients with EH were teated with metoproiol 25 mg.bid for 4 weeks. The G protein β3 subunit gene C825T polymorphism was genotyped by gene chip technique. The decrease of systolic blood pressure(SBP) and mean arterial pressure( MAP) were compared between two genotype groups of CT o +TT and CC. Results The reductions in SBP and MAP of CT+TT genotype group were (21. 07± 12. 04) mm Hg and (13. 33±7. 31) mm Hg, respectively,which were significantly more than (9. 44± 14. 65) mm Hg and (7. 07±7. 34) mmHg of CC genotype group(P<0. 05). There was no significant difference in the reduction of diastolic blood pressure between groups of CT+TT and CC genotype. Conclusion The G protein β3 subunit gene C825T genotype is associated to the hypotensive efficacy of metoproloL The reductions in SBP and MAP are greater in EH patients carrying T allele.%目的 探讨原发性高血压(EH)患者G蛋白β3亚单位基因的C825T多态性与美托洛尔降压疗效的关系.方法 EH患者52例,口服美托洛尔25 mg/次,每天2次,连续服用4周.采用基因芯片技术进行基因多态性检测,分析不同基因型之间血压下降值的关系.结果 服用美托洛尔治疗4周后,CT+TT基因型患者(43例)收缩压的下降值为(21.07±12.04)mm Hg·平均动脉压的下降值为(13.33±7.31)mmHg,均明显大于CC基因型患者(9例)的(9.44±14.65)mmHg和(7.07±7.34) mm Hg(P＜0.05).但两组之间舒张压下降值无统计学差异.结论 G蛋白β3亚单位基因的C825T多态性与美托洛尔降压疗效相关.携带T等位基因的患者收缩压及平均动脉压下降更明显.