Objective To compare the efficacy of live combined Bifidobacterium and Lactobacillus(LBBLB) and Bacillus subtilis duplex living bacterium(BSDLB) in treating Helicobacter pylori(Hp) infection .Methods A total of 100 patients with Hp infection was treated with standard triple therapy ,who were equally randomized into two groups of A(additional oral use of LBBLB ,630 mg bid .× 14 days) and B(additional oral use of BSDLB ,1000 mg bid .× 14 days) .The clinical efficacy and adverse effects were compared between two groups .Hp infection was examined one month after stopping treatment .Results The total effectiveness rate of group A was similar to that of group B (96% vs .88% ) ( P＞0 .05 ) .So did the ulcer healing rate (86.0% vs .80.0% ) ( P＞0 .05 ) .The eradication rate was higher in group A than that in group B(92.0% vs .80.0% )(P＜0 .01) .The adverse effects during treatment were abdominal distension ,nausea ,diarrhea ,dizziness and loss of appetite .The incidence rates of adverse effects were 4.0% and 2.0% ,respectively for group A and group B(P＞0 .05) .Conclusion On the basis of triple therapy ,the eradication rate of Hp is higher with additional use of LBBLB than that with additional use of BSDLB .%目的 比较两种不同益生菌治疗幽门螺杆菌(Hp)的临床疗效.方法 Hp感染患者100例均分为两组 ,均采用规范三联疗法.A组加用双歧杆菌三联活菌(LBBLB)治疗 ,630 mg ,每日口服2次 ;B组加用枯草杆菌二联活菌(BSDLB)1000 mg ,每日口服2次治疗.疗程14 d ,停药后1个月复查Hp.比较两组临床疗效和不良反应发生率.结果 治疗后 ,A组和B组临床有效率和溃疡愈合率相仿(96.0% vs .88.0% 和86.0% vs .80.0% )(P＞0 .05);A 组治疗后 Hp根除率高于B组(92.0% v s .80.0% )( P＜0 .01 ).治疗期间的不良反应主要有腹胀、恶心、腹泻、头晕和食欲减退等;A组和B组不良反应发生率相仿(4.0% vs .2 .0% )(P＞0.05).结论 在规范三联疗法治疗的基础上 ,加用LBBLB治疗 Hp根除率高于加用BSDLB.
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