辛伐他汀治疗糖尿病合并冠心病的疗效观察

摘要

目的 观察辛伐他汀治疗糖尿病合并冠心病的临床疗效.方法 选择47例糖尿病合并冠心病患者,均给予口服辛伐他汀20mg/次,1天1次,连续治疗12周,治疗前后均检测患者血糖、血脂、血浆一氧化氮(NO)与内皮索(ET)水平以及血清定粉样蛋白A(A-SAA),并测定血管内皮细胞的功能.结果 47例患者经过12周的治疗,血脂和肱动脉内皮依赖性舒张功能显著改善,ET水平明显降低,NO明显升高,A-SAA水平降低,与治疗前比较差异均有统计学意义(P<0.05,P<0.01).结论 辛伐他汀通过降脂和平衡NO/ET的比值等途径保护内皮功能,通过降低A-SAA水平可以抵抗动脉粥样硬化的作用.%Objective To observe the efficacy of simvastatin for diabetes mellitus with coronary heart disease. Methods 47 diabetic patients with coronary heart disease patients were chose to treat with oral simvastatin of 20mg once daily for 12 weeks. Before and after treatment, blood levels of sugar, lipids, nitric oxide( NO ), endothelin, and serum amyloid A protein( SAA )were detected, so was the function of vascular endothelial cells. Results After a 12-week therapy, levels of lipids and brachial arterial endothelium-dependent vasodilation were markedly improved, levels of ET and SAA declined and NO level elevated, with a statistical difference ( P < 0.05 and P < 0.01 ). Conclusions Simvastatin can protect endothelial function by reducing lipid levels and balancing the NO/ET ratio and play an anti-atherosclerotic role by lowering SAA levels.