高血压病患者血清脂联素水平与左心室几何构型的关系

摘要

Objective To investigate the relationship between serum adiponectin ( APN ) level and left ventricular geometry in patients with essential hypertension. Methods Echocardiography was performed on 133 patients with essential hypertension. According to left ventricular mass index ( LVMI) and relative wall thickness ( RWT ), patients were divided into normal geometry group ( n = 37 ), concentric remodeling group ( n=32 ), concentric hypertrophy group ( n = 34 )and eccentric hypertrophy group ( n = 30). 30 healthy subjects were used as control. Serum APN levels were measured by enzyme-linked immunosorbent assay. Results Serum APN levels did not differ significantly among the control group, the normal geometry group, and the concentric remodeling group ( P>0.05 ). As compared with those in the control group, serum APN levels were markedly lower in the concentric hypertrophy group and the eccentric hypertrophy group ( P< 0.01 ), especially in the latter group ( P< 0.01 ). APN levels were negatively related with LVMI ( P < 0.05 ) in those with ventricular hypertrophy. Conclusions Serum APN levels can still reflect the degree of left ventricular hypertrophy in hypertensive patients receiving standard therapies.%目的 探讨高血压病患者左心室重构的不同阶段血清脂联素(APN)水平与左心室几何构型的关系.方法 对133例高血压病患者进行超声心动图检查,依据左心室质量指数、左心室相对室壁厚度将患者分为左心室正常构型组、左心室向心性重构组、左心室向心性肥厚组和左心窒离心性肥厚组.30例健康体检者为对照组.ELISA法测定血清APN水平.结果 对照组、左心室正常构型组、左心室向心性重构组之间血清APN水平比较差异无显著性(P>0.05).与对照组比较,左心室向心性肥厚组和左心室离心性肥厚组高血压病患者的血清APN水平显著降低(P<0.01),且左心室离心性肥厚组APN水平下降的更明显(P<0.01).左心室肥厚组患者的血清APN水平与左心室质最指数呈显著的负相关(P<0.05).结论 在规范化治疗的高血压病患者,血清APN水平仍能很好的反映左心室肥厚的程度.