丹参药液经皮透入综合治疗对血管性痴呆患者P300的影响

摘要

Objective To examine the role of comprehensive percutaneous permeation of radix salviae miltiorrhizae in treating event-related potentials( P300 )of vascular dementia patients. Methods A total of 60 patients were randomly classified into two groups: the treatment group( percutaneous permeation of radix salviae miltiorrhizae ) and the control group. The two groups were measured by means of Hasegawa s Dementia scale(HDS),activity of daily living (ADL) and event-related potentials (P300 ) by physical therapist before and after treatment. Results Compared with the control group, the treatment group manifested shorter latency and higher amplitude of Target P3 wave of P300 after treatment ( P＜0.01), and there was also significant difference in HDS and P300 within the treatment group before and after treatment (P ＜0.01). Conclusion Comprehensive percutaneous permeation of radix salviae miltiorrhizae is effective in improving the cognitive ability of vascular dementia patients, and it's also an assistant therapy method and one of the preventive measures for vascular dementia patients..%目的 研究丹参药液经皮透入综合治疗对血管性痴呆(vascular dementia,VD)患者事件相关电位(P300)的影响.方法 对60例血管性痴呆患者随机分为经皮药物透入治疗组及对照组,治疗前后由专业治疗师对两组患者分别进行修改长谷川痴呆量表(HDS)评定以及事件相关电位(P300)检查等.结果 经丹参药液经皮透入综合治疗后,总有效率对照组为36.66%,治疗组为66.66%,HDS(x)对照组为11.78,治疗组为18.35,两组之间差异有极显著性(P＜0.01),治疗组优于对照组;治疗后治疗组与对照组患者P300波幅(x)分别为7.77 uv和5.76 uv,潜伏期(x)分别为301.18 ms和385.03 ms,治疗组患者P300波幅升高,潜伏期缩短,与对照组比较差异有极显著性(P＜0.01).同时,治疗组组内HDS和P300波幅与潜伏期的治疗前后差异也有极显著性(P＜0.01).结论 丹参药液经皮透入综合治疗能较好地改善血管性痴呆患者的认知能力,可作为血管性痴呆患者的辅佐治疗手段及早期预防措施之一.