比索洛尔与培哚普利联合对慢性心衰患者血浆pro-bnp水平干预作用研究

摘要

Objective To investigate the intervention effect of serum pro-bnp of bisoprolol combined with perindopril in patients with chronic heart failure Methods 120 cases with chronic heart failure of our hospital were randomly divided into 3 groups, bisoprolol group, perindopril group and bisoprolol combined with perindopril group, 40 cases for each group, the serum pro-bnp was determined before and after treatment, observed the curative effect.Results The total effective rate of combined treatment group was 95.0%, that was better than the bisoprolol group (80.0%) and perindopril group (77.5%),P＜0.05 ,after treatment, the level of serum pro-bnp of combined treatment group was less than that of bisoprolol group and perindopril group, P＜0.05.Conclusion bisoprolol combined with perindopril can decrease the level of serum pro-bnp significantly, the curative effect is exact.%目的 探讨比索洛尔与培哚普利联合对慢性心衰患者血浆脑钠肽前体(pro-bnP水平的干预作用.方法 选取本院收治的120例慢性心衰患者,随机分为3组,每组40例,即比索洛尔组、培哚普利组和比索洛尔联合培哚普利组,测定治疗前后血浆pro-bnp水平,观察疗效.结果 联合治疗组总有效率为95.0%,显著优于比索洛尔组(80.0%)和培哚普利组(77.5%),P＜0.05,治疗后血浆pro-bnp水平联合治疗组显著低于比索洛尔组和培哚普利组,P＜0.05.结论 比索洛尔和培哚普利联合用药能够显著降低患者的血浆pro-bnp水平,疗效确切.