氯沙坦对老年高血压患者心肌纤维化改善效果的临床研究

摘要

目的 观察氯沙坦对老年高血压患者心肌纤维化的影响.方法 对44例老年高血压心肌纤维化患者口服氯沙坦(50 ～100 mg/d)治疗12～16个月,观察治疗前后患者血压和心肌纤维化改善情况.采用酶联免疫法在治疗前后各测一次血浆中Ⅲ型胶原前肽、层粘连蛋白.结果 氯沙坦治疗后血压明显下降(P＜0.01),心率无明显变化(P＞0.05),心肌纤维化指标:Ⅲ型前胶原氨基末端肽(PⅢP)、层粘连蛋白(LN)均明显降低(P＜0.05).结论 氯沙坦在有效降压的同时,部分逆转或减轻心肌纤维化,对心率无明显影响.%Objective To investigate the effect of losartan on myocardial fibrosis in elderly patients with hypertension.Methods 44 elderly patients with hypertension and myocardial fibrosis were treated with oral losartan (50-100 mg/d) for 12-16 months.And the improved conditions of myocardial fibrosis and blood pressure were observed before and after treatment.Measured type Ⅲ ex-collagen and laminin with ELISA before and after treatment.Results After treatment,blood pressure decreased significantly (P＜0.01),heart rate did not change significantly (P＞0.05),type Ⅲ ex-collagen and laminin decreased significantly (P＜0.05).Conclusion Losartan can effectively decrease blood pressure,partly reverse or attenuate myocardial fibrosis,and has no significant effect on heart rate.