宫颈癌根治术中不同麻醉方式对患者免疫功能的影响

摘要

Objective To study the impact of different anesthesia methods on immune function in patients with radical operation of cervical cancer.Methods 60 patients undergoing radical operation of cervical cancer in our hospital from December 2013 to November 2015 were divided into epidural anesthesia group (30 cases) and general anesthesia group (30 cases) according to the mode of anesthesia.The levels of T lymphocyte subsets and NK cells were detected and compared before and after anesthesia in two groups.Results The serum levels of CD3+,CD4+,CD4+/CD8+,and NK cells after operation,postoperative 24 h and 3 d were significantly lower than those before anesthesia in two groups (P＜0.05).The observation indexes recovered to the levels before anesthesia after postoperative 5 d in epidural anesthesia group,and postoperative 7 d in general anesthesia group.Conclusion Compared with general anesthesia,epidural anesthesia has more advantages in the immune function preservation of patients with radical operation of cervical cancer.%目的 研究官颈癌根治术中不同麻醉方式对患者免疫功能的影响.方法 选取2013年12月至2015年11月在本院行官颈癌根治术的患者60例,根据麻醉方式分为硬麻组(30例)和全麻组(30例),检测两组患者麻醉前后血清T淋巴细胞亚群和NK细胞水平,并进行统计比较.结果 两组在术毕、术后24 h、术后3d时血清CD3+、CD4+、CD4+/CD8+和NK细胞水平均较麻醉前明显下降(P＜ 0.05);至术后5d时,硬麻组各观测指标恢复至麻醉前水平,而全麻组术后7d恢复.结论 与全身麻醉比较,硬膜外麻醉在保护官颈癌根治术患者的免疫功能方面更具优势.