茶碱缓释片联合噻托溴铵对稳定期COPD患者夜间睡眠低氧的临床疗效研究

摘要

Objective To explore the clinical efficacy of tiotropium bromide combined with theophylline sustained-release tablets for nocturnal sleep hypoxemia in patients with stable chronic obstructive pulmonary disease (COPD).Methods 82 patients with COPD sleep hypoxemia treated at our hospital from March,2015 to March,2016 were randomly selected as study objects and were divided into a control group and an observation group,41 for each group.The control group were treated with tiotropium bromide and the observation group with tiotropium bromide and theophylline sustained-release tablets.The nocturnal sleep oxygen saturation,blood gas analysis,and pulmonary function were observed in both groups.Results There were statistical differences in nocturnal sleep oxygen saturation,blood gas analysis,and pulmonary function between after and before the treatment in the observation group and between these two groups after the treatment (all P ＜ 0.05).Conclusions Tiotropium bromide combined with theophylline sustained-release tablets can improve the stability of COPD patients with nocturnal sleep hypoxemia and their blood gas analysis,and pulmonary function and is highly safe.%目的 探讨噻托溴铵联合茶碱缓释片对稳定期COPD患者夜间睡眠低氧的疗效.方法 随机选择2015年3月至2016年3月本院收治的慢性阻塞性肺疾病睡眠低氧患者82例作为本次研究对象,将其平均分为对照组41例和观察组41例.对照组噻托溴铵治疗,观察组噻托溴铵联合茶碱缓释片治疗,观察比较两组夜间睡眠血氧饱和度、血气分析及肺功能指标.结果 观察组治疗后夜间睡眠血氧饱和度与治疗前比较,差异具有统计学意义(均P＜ 0.05);治疗后,观察组夜间睡眠血氧饱和度与对照组比较,差异具有统计学意义(均P＜ 0.05).观察组治疗后血气分析与治疗前比较,差异具有统计学意义(P＜ 0.05)治疗后,观察组和对照组血气分析比较,差异具有统计学意义(均P＜ 0.05).观察组治疗后肺功能与治疗前比较,差异具有统计学意义(均P＜ 0.05);治疗后,观察组肺功能与对照组比较,差异具有统计学意义(均P＜ 0.05).结论 噻托溴铵联合茶碱缓释片可进一步改善稳定期COPD患者的夜间睡眠低氧、血气分析和肺功能,且安全性高.