细胞层片移植的研究现状

摘要

Although tissue engineering has been thought of having great potential in organ regeneration, there are still some bottlenecks, such as immune rejection of the scaffold materials, inflammation caused by fibrosis as well as cell proliferation within the stent material. Cell sheet transplantation, by which cultured cells can be harvested as intact sheets, has much superiority over traditional tissue engineering. The cell sheet, with no need of scaffold,can be transplanted by single piece or forming three-dimensional structure through same or a different cell sheet stack with each other. It avoids the complication of scaffold material degradation and will have a prosperous application in the future.%组织工程技术为器官重建带来了希望,然而,宿主对支架材料的免疫排斥和炎症反应带来的纤维化和细胞在支架材料内部的增殖状态,仍是亟待解决的问题.细胞层片移植使用特定的方法获得保留了完整细胞外基质的细胞层片,不需支架材料,通过相同或不同的细胞层片相互层叠,获得全细胞的三维组织,克服了传统组织工程支架材料降解的限制,具有良好的应用前景.