口腔癌患者情绪异常与下丘脑-垂体-肾上腺轴的调节障碍

摘要

Oral cancer is the most common neoplasm of the head and neck. Patients with oral cancer show elevated prevalence rates of mood disorder. Mood disorder is a kind of catalyst' in the development of cancer and the prognosis predictor. Mood disorder in oral cancer may be associated with circadian disruption in hypothalamic-pituitary-adrenal (HPA) axis. Based on this analysis, we recommend that alteration of circadian rhythm of the HPA axis may play a crucial role in biology mechanism of intervention on oral cancer with mood disorder.%口腔癌是头颈部最常见的肿瘤,患者多伴有焦虑或抑郁情绪,而情绪异常又是癌症发生发展的"催化剂"和预后的预报器.口腔癌的情绪异常与下丘脑-垂体-肾上腺(HPA)轴调节紊乱应有一定关联性.本文提示以神经内分泌莺要环节--HPA轴调节紊乱为重要切入点,探讨口腔癌情绪异常的生物学机制,可为口腔癌的情绪异常及其干预措施的机制研究提供新思路,具有重要意义.