聚醚醚酮复合材料及其表面改性后的成骨效能

摘要

Polyetheretherketone(PEEK) is a new organic polymer compound. Considering its poor osteogenetic efficiency, PEEK has not been widely used in clinical settings. The disadvantages of PEEK can be overcome by combining PEEK with different components in a composite to increase its osteogenetic efficiency. Studies showed that PEEK-hydroxyapatite composite exhibits good osteogenetic potency, but its brittleness is high and its mechanical properties are low. Carbon fiber can resolve these disadvantages. Fluorapatite PEEK and nano-titania-PEEK composites can also increase the osteogenetic efficiency of PEEK. Surface sandblasting, plasma spraying, laser and electric arc ion plating, chemical etching, growth factor promotion, and biological coating modification can effectively increase the biological activity and osteogenesis of PEEK, resulting in novel applications for prosthodontics and implantology. This article summarizes recent work on the osteogenetic performance of PEEK and its compositesto provide theoretical basis for its clinical application.%聚醚醚酮（PEEK）为一种新型有机高分子化合物，其表面成骨效能较低，故未能广泛应用于临床。以不同的方法处理PEEK，可提高其成骨效能，克服其不足之处。研究证实，PEEK-羟磷灰石（HA）复合材料具有良好的成骨效能，但其脆性较PEEK增大，力学性能降低。将其制成PEEK-HA-碳纤维复合材料，可弥补PEEK-HA复合材料脆性较高的缺点。纳米氟磷灰石-PEEK复合材料和纳米二氧化钛-PEEK复合材料均可提高成骨效能。PEEK经过表面喷砂、等离子喷涂、激光照射、电弧离子镀层、化学酸蚀刻、生长因子促进和生物涂层改性后，可以有效地提高材料的生物活性和成骨效能，为口腔修复和种植治疗带来新的可能。本文总结PEEK及其复合材料成骨效能的最新研究进展，旨在为其临床应用提供理论依据。