原发性干燥综合征患者萎缩性舌炎发病情况及相关因素研究

摘要

Objective   To identify the independent risk factors of atrophic glossitis and the influence factors of atrophic glossitis degree in primary Sjögren’s syndrome(pSS) patients. Methods   The clinical data of 36 cases of pSS patients were collected and taked the tongue back photos, graded the level of the atrophy of tongue papillae on the back of the tongue. Clinical manifestation, subjective symptoms and extractable nuclear antigens(ENA) spectrum were compared between the pSS patients with atrophic glossitis and without atrophic glossitis. The risk factors that may cause atrophic glossitis were analyzed by univariate and multivariable Logistic regression analysis and chi-square test. Results   There were 18 patients in 36 pSS patients(50%) with atrophic glossitis. Age>65, and Ro-52 positive were the risk factors of atrophic glossitis occurred in patients with pSS. Age>65 affected the incidence of atrophic glossitis degree. There was a statistically difference between groups(P<0.05). Conclusion   Atrophic glossitis is a common complication of pSS. Age and Ro-52 positive is risk factors affecting pSS patients with atrophic glossitis and aggravating atrophic glossitis. The degree of atrophic glossitis increaseed with age in pSS patients.%目的：   探讨原发性干燥综合征（pSS）伴发萎缩性舌炎的危险因素，及伴发萎缩性舌炎舌乳头萎缩程度的相关危险因素。方法   采集36例pSS患者临床资料，拍摄舌背部高清晰度照片，对舌背舌乳头是否伴发萎缩性舌炎及舌乳头萎缩程度进行评价分级，分析患者的临床表现、主观症状和可提取性核抗原（ENA）酶谱的差别，利用单因素及多因素回归方法分析pSS伴发萎缩性舌炎的危险因素，及伴发萎缩性舌炎舌乳头萎缩程度的相关危险因素。结果   多因素回归分析显示：年龄大于65岁以及抗Ro-52抗体阳性是pSS伴发萎缩性舌炎的危险因素，不同年龄段间舌乳头萎缩程度的差异有统计学意义（P<0.05）。结论   年龄大于65岁及抗Ro-52抗体阳性是pSS伴发萎缩性舌炎的危险因素，pSS伴发萎缩性舌炎舌乳头萎缩程度随年龄增长而加重。