促牙本质再矿化的生物活性树脂研究进展

摘要

诱导混合层裸露胶原再矿化是提高树脂牙本质粘接耐久性的重要方法.然而粘接界面有限的矿化离子源限制了牙本质再矿化的临床应用.采用无机材料对粘接树脂改性,可制备出具有生物活性的树脂修复材料,这些树脂在溶液中可缓慢释放矿化离子(如Ca2+、pO43-、OH-等),具有促进脱矿牙体组织再矿化的潜能.用于树脂改性的无机材料包括硅酸盐、磷酸钙盐、生物活性玻璃等.研究证实生物活性树脂修复材料具有促进脱矿牙本质再矿化、抑制胶原纤维降解的能力,但在树脂中添加无机材料会影响树脂的力学性能,制备具有良好力学性能的生物活性树脂是研究的重点和难点.本文将分类阐述不同生物活性树脂修复材料在牙本质再矿化中的作用.%Dentin remineralization is one of the most important methods to improve resin-dentin bonding durability.However,the limited mineral ion supply limits the remineralization of demineralized dentine.Experimental adhesives doped with inorganic fillers are proven bioactive and can release mineral ions.These inorganic materials include silicate,calcium phosphate,and bioactive glass.Many studies have proven that these bioactive resins can induct the remineralization of dentine and protect collagen fibrils.Some of the studies also showed the poor mechanical properties of the resins.Synthesizing new bioactive resins with excellent mechanical properties is important.This review presents the effects of the bioactive restorative composite in dentin remineralization.