目的 探讨益肾活血助孕汤治疗排卵障碍性不孕症的机制.方法 构建排卵障碍性不孕症大鼠模型,给予益肾活血助孕汤治疗,检测卵巢颗粒细胞内Ca2+(Ca2+i)浓度.结果 与对照组比较,模型组卵巢颗粒细胞Cai2+浓度显著降低(P＜0.05);中药治疗组Cai2+浓度明显高于模型组(P＜0.05).结论 益肾活血助孕汤能提高排卵障碍性不孕症模型大鼠卵巢颗粒细胞Cai2+浓度,从而达到治疗排卵障碍性不孕症的目的.%Objective To investigate the mechanism of tonifying kidney promoting blood flow assist fetation soup for the treat ment of ovulation failure. Methods Rat model of ovulation failure was constructed and treated with tonifying kidney promoting blood flow assist fetation soup and then the contents of intracellular Ca2+ (Cai 2+ ) in ovaries granulocytes were measured. Results Compared with control group, the level of Cai2+ in ovaries granulocytes significantly decreased in model group(P＜0.05). Com pared with model group, the level of Cai 2+ in ovaries granulocytes increased significantly in treated group(P＜0.05). Conclusion Tonifying kidney promoting blood flow assist fetation soup could increase the level of Cai2+ in ovaries granulocytes of the rat model of ovulation failure and could be used for the therapy of ovulation failure.
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