精神分裂症患者血清免疫球蛋白核心岩藻糖基化水平与体液免疫指标的相关性研究

摘要

目的：研究精神分裂症患者血清免疫球蛋白核心岩藻糖基化水平与体液免疫各项指标之间的关系，探讨其免疫学意义。方法采用直线相关分析法，研究46例精神分裂症组和47例对照组血清小扁豆凝集素（LCA ）-IgM、LCA-IgG、LCA-IgA水平，与血清IgM、IgG、IgA、循环免疫复合物（CIC）水平的相关性。结果对照组血清LCA-IgA 水平与 IgG水平呈正相关（r＝0．3117，P＜0．05）。精神分裂症组血清LCA-IgG水平与IgA水平呈负相关（r＝-0．3236，P＜0．05），精神分裂症组血清LCA-IgM、LCA-IgG、LCA-IgA水平均与CIC水平呈正相关（r＝0．3548，r＝0．1898，r＝0．4797，P＜0．05）。结论精神分裂症患者血清免疫球蛋白发生了过度岩藻糖基化，并参与患者的中枢神经系统免疫损伤的病理过程。%Objective To investigate the correlation between the levels of serum immunoglobulin core fucosylation and humoral immune parameters in patients with schizophrenia and its immunological significance .Methods The levels of serum lens culinaris agglutinin(LCA)-IgM ,LCA-IgG ,LCA-IgA ,IgM ,IgG ,IgA ,circular immune complex(CIC) in patients with schizophrenia(n= 46) and health people(n=47) were determined .Their correlations were investigated by linear regression analysis .Results There was a positive correlation between the LCA-IgA and IgG in healthy people(r=0 .311 7 ,P<0 .05) .However ,there was a negative correla-tion between LCA-IgG and IgA in patients with schizophrenia(r=0 .323 6 ,P<0 .05) .In addition ,there were positive correlations between LCA-IgM ,LCA-IgG ,LCA-IgA and CIC(r=0 .354 8 ,r=0 .189 8 ,r=0 .479 7 ,P<0 .05) .Conclusion Increased fucosyla-tion levels of immunoglobulin were detected in patients with schizophrenia ,which may play important roles in immunological inju-ries of central nervous system in schizophrenia .