甲状腺功能亢进合并乳腺增生男性患者的性激素变化情况

摘要

Objective To investigate the effect of methimazole on male patients with hyperthyroidism and hyperplasia of mammary glands and its effect on sex hormone levels.Methods A total of 97 cases of hyper-thyroidism treated in the hospital from February 2014 to February 2017 were selected as the research subjects. These patients were divided into group A (patients with hyperthyroidism with mammary gland development , 33 cases) and group B (patients with hyperthyroidism ,64 cases) according to whether patients had the combi-nation of hyperplasia of mammary glands.Two groups of patients were treated with methimazole ,thyroid hor-mone levels and sex hormone levels before and after treatment were compared between the two groups.Results Before treatment ,there was no significant difference in the levels of free T 3 (FT3) ,free T4 (FT4) ,three io-dine thyroxine (T3) ,thyroxine (T4) ,and thyroid stimulating hormone (TSH) in the two groups (P＞0.05). After treatment ,the levels of FT3 ,FT4 ,T3 and T4 in both groups were significantly lower than those before treatment ,while the level of TSH was significantly higher than that before the treatment (P＜0.05).There was no significant difference in the levels of FT 3 ,FT4 ,T3 ,T4 and TSH between the two groups (P＞0.05). Before treatment ,the levels of total testosterone (T) ,luteinizing hormone (LH) ,prolactin (PRL) and estradi-ol (E2) in group A were significantly higher than those in the B group (P＜0.05).After treatment ,the levels of T ,LH ,PRL and E2 in group A were significantly lower than those before treatment (P＜0.05).After treat-ment ,the levels of T ,LH ,FSH ,PRL ,E2 ,P in the two groups were not statistically significant (P＞0.05). Conclusion Patients with hyperthyroidism combined with hyperplasia of mammary glands has a high level of sex hormones.After hyperthyroidism treatment ,thyroid hormone and sex hormone levels can be significantly changed into a better status.%目的 探讨甲巯咪唑对甲状腺功能亢进合并乳腺增生男性患者治疗效果及其对性激素水平影响.方法 选取2014年2月至2017年2月该院诊治的甲状腺功能亢进男性患者97例作为研究对象.根据是否合并乳腺增生将其分为A组(甲状腺功能亢进合并乳腺发育患者)33例和B组(单纯甲状腺功能亢进患者)64例.两组患者均采用甲巯咪唑治疗,比较两组患者治疗前后甲状腺激素水平及性激素水平.结果 治疗前,两组患者游离 T3(FT3)、游离T4(FT4)、三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)水平比较,差异无统计学意义(P＞0.05) ;治疗后,两组患者FT3 、FT4 、T3 、T4水平较治疗前均显著降低,TSH水平较治疗前显著升高,差异有统计学意义(P＜0.05) ,而两组患者FT3 、FT4 、T3 、T4 、TSH水平比较,差异无统计学意义(P＞0.05).治疗前,A组患者总睾酮(T)、促黄体生成激素(LH)、催乳素(PRL)、雌二醇(E2)水平显著高于B组,差异有统计学意义(P＜0.05) ;治疗后,A组患者T 、LH 、PRL 、E2水平较治疗前显著降低,差异有统计学意义(P＜0.05) ,而两组患者 T 、LH 、卵泡刺激素(FSH)、PRL 、E2 、孕酮(P)水平比较,差异无统计学意义(P＞0.05).结论 甲状腺功能亢进合并乳腺增生患者性激素水平较高,经甲亢治疗后能显著改善患者甲状腺激素和性激素水平.