骨髓间充质干细胞神经保护作用在视网膜疾病治疗中的研究进展

摘要

骨髓间充质干细胞（ MSCs）是来源于骨髓的具有多种神经营养因子分泌功能的多能干细胞，被广泛应用于组织、细胞的修复或替代研究中。有研究表明MSCs分泌的多种神经营养因子，有助于提高病理状态下神经细胞的存活能力。因此，MSCs的神经保护功能也逐渐被应用于视网膜疾病的研究中。视网膜细胞对损伤非常敏感且自我修复能力较差，利用MSCs的这一功能可为病变视网膜的治疗带来新的希望。本文就MSCs的神经营养因子分泌功能及其对视网膜细胞产生的神经保护作用和在不同视网膜疾病中的研究应用进展等方面进行综述，并展望其在视网膜疾病治疗中的应用前景。%· Mesenchymal stem cells ( MSCs ) are a population of multipotent stem cells with various neurotrophins from bone marrow which are widely used in tissue, cell repair and alternative research.Recently, some researches have shown that MSCs could enhance the viability of neurons under a pathological circumstance by secreting some neurotrophins. So the neuroprotection of MSCs can provide a new method of the treatment on retinopathy that it possible to promote cells survial and functional recovery.Here we make a brief review on the secretory function of neurotrophin and neuroprotective effects of MSCs on retinal cells and its application in the treatment of retinal disease.