玻璃体内注射贝伐单抗联合视网膜激光光凝治疗糖尿病性黄斑水肿

摘要

目的：探究玻璃体内注射贝伐单抗联合视网膜激光光凝治疗糖尿病黄斑水肿的治疗效果以及分析此方法的安全性。　　方法：选取2014-02/2015-03期间于我院确诊并治疗的69例82眼糖尿病黄斑水肿,随机平均分为对照组与观察组,每组41眼。观察组患者行玻璃体内注射贝伐单抗联合视网膜激光光凝治疗,对照组行单纯视网膜激光光凝治疗。治疗后观察并对比两组患者最佳矫正视力情况(BCVA)、黄斑中心凹厚度(CMT)、荧光素眼底血管造影改变( FFA)以及眼压变化等并发症情况。　　结果：观察组于治疗后1、3、6 lo BCVA、CMT较治疗前有明显改善( P0.05),CMT较治疗前有所降低(P0. 05) and CMT decreased at 1,3 and 6mo (P<0. 05) , but the result of FFA rebounded at 6mo. There were significant differences between two groups on BCVA and CMT after treatment (P<0. 05). None of patients in two groups got any local or systemic complication at 1,3 and 6mo after treatment. CONCLUSlON: lntravitreal injection of bevacizumab combined with laser photocoagulation for diabetic macular edema is much more effective and has less complication . lt is worth promoting in clinical application.