糖尿病周围神经病变与NF-κB、TNF-α和HSP70的关系

摘要

糖尿病周围神经病变(DPN)是一种常见的糖尿病并发症，主要发病机制与高血糖引起的代谢紊乱、氧化应激、神经营养障碍及遗传因素等有关。氧化应激可以通过包括多元醇途径、己糖胺途径、蛋白激酶C途径的激活以及糖基化终末产物(AGES)的形成等代谢途径间接引起神经元和轴突的损伤，同时直接损伤了神经细胞。其中NF-κB、TNF-α和HSP70在糖尿病周围神经病变的氧化应激的过程中扮演了不同角色。%Diabetic peripheral neuropathy (DPN) is one of the common complications of diabetes, its pathogenesis shows a rela-tionship with some reasons,such as metabolic disorders, oxidative stress, nerve nutrition disorder, vascular injury and genetic factors, which caused by high blood sμgar. Oxidative stress can be achieved by some metabolic pathways, including polyol pathway, hexose amine way, the activation of protein kinase C pathway and the formation of advanced glycation end products(AGES), to indirect cause damage to neurons and axons.And they also can damage to nerve cells directly. The NF-κB, TNF-αand HSP70 play different roles in oxidative stress of diabetic peripheral neuropathy different links.