目的:探讨联合监测血清孕酮及抑制素A在预测早期先兆流产预后的临床意义.方法:观察156例孕5-12周单胎孕妇,根据妊娠结局分为3组,正常妊娠组60例,先兆流产组60例,难免流产组36例,各组无年龄、孕产次及体重差异.采用酶联免疫吸附法(ELISA)测定血清孕酮及抑制素A.结果:成功妊娠者血清孕酮及抑制素A浓度明显高于失败结局者,差异有统计学意义(P＜ 0.05).孕酮＜14.3 ng/mL为临界值,预测流产敏感性、特异性及准确性为72.1％、78.6％ and78.1％,联合以推荐血清抑制素A＜ 144.95pg/mL为临界值预测难免流产联合孕酮临界值,预测难免流产的敏感性、特异性及准确性分别为88.2％、84.2％、90.6％.结论:联合测定血清孕酮及抑制素A比其单项测定指标可显著提高对先兆流产结局预测的准确率.%Objective: To explore the clinical significance of combine serum progesterone and inhibin A in prediction of outcomes of threatened abortion. Method: Clinical data of 156 cases of early monovular pregnancy (5-12 weeks) were divided into three groups; normal intrauterine pregnancy group,threatened a-bortion group and inevitable abortion group, each with 60 cases. Serum progesterone and inhibin A level were assayed with ELISA in all the cases. Result: The progesterone level of inevitable abortion was significantly lower than that of threatened abortion ( P<0. 05). The serum inhibin A level of inevitable abortion was significantly higher than that of threatened abortion (P < 0. 05 ). The serum progesterone and inhibin A level assay was valuable in detecting inevitable abortion. Separate serum progesterone < 14 .3 ng/mL,The sensitivity, specificity and accuracy were 72.1% ,78.6% and 78. 1%. If combine with inhibin A <144. 95pg/ mL, the three rates would be 88.2% ,84.2% ,90.6%. Conclusion: Combine serum progesterone and inhibin A level assay is more valuable than single index in forecast the outcome of threatened abortion.
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