目的:观察奥美沙坦联合氨氯地平治疗原发性中度高血压的疗效和不良反应,并与贝那普利联合氢氯噻嗪疗法进行对比.方法:将我院2009年12月至2010年4月诊治的80例原发性中度高血压患者随机分为治疗组和对照组.治疗组予以奥美沙坦(40mg,每日早8点一次)、氨氯地平(10mg,每日早8点一次)口服治疗,持续4周;对照组予以贝那普利(20mg,每日早8点一次)、氢氯噻嗪(25mg,每日早8点一次)口服治疗,持续4周.所有患者治疗前后均测量血压,治疗过程中密切观察出现的不良反应.治疗结束后比较治疗组和对照组的疗效和不良反应.结果:奥美沙坦联合氨氯地平疗法与贝那普利联合氢氯噻嗪疗法在疗效上有统计学差异,且前者的不良反应较轻.结论:奥美沙坦联合氨氯地平在治疗原发性中度高血压中高于贝那普利联合氢氯噻嗪疗法的疗效,且能够减轻治疗中出现的不良反应.%To observe the effectiveness and adverse reaction of olmesartan associated with amlodipine for patients with primary moderate hypertension, make a comparison with the therapy of benazapril associated with hydrochlorothiazide. Method: 80 primary moderate hypertension patients diagnosed in our hospital between December 2009 and April 2010 were randomly divided into the treatment group and control group. Patients in treatment group were given olmesartan(40mg,once per 8am) associated with amlodipine( 10mg,once per 8am) oral administrations control group were given benazapril(20mg,once per 8am) associated with hydrochlorothiazide(25mg, once per 8am) omi administrations which lasted for 4 weeks. Every subject was measured blood pressure before and after the treatment, and observed adverse reaction may appeared. After the treatment, made a comparisonin aspects of effectiveness and adverse reaction between two Stoups. Result: There was significant difference in effectiveness of two therapies, and the treatment group adverse reaction was lighter than that in control group. Conclusion: The therapy of olmesartan associated with amlodipine is more effective than the therapy of benazapril associated with hydrochlorothiazide, also reduce the adverse reaction.
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