Objective: To explore the rational application of antibiotics for perioperation of the elective cesarean delivery. Method: 178 parturient women of the elective cesarean delivery were randomly divided into 3 groups ( A , B , C ), and ampicillin was used by intravenous injection in perioperation . Group A ( n = 50 ) received the single dose infusion of antibiotics after umbilical cord was severed during operation. Group B ( n = 70 ), The antibiotics were injected twice: the first time was immediately used postoperatively and the other in 6 hours of postoperation. Group C ( n = 58 ), The antibiotics were injected twice a day for two days postoperatively and the first was used in half hour of postoperation. And then compared the result of medicine index including fever,white blood cell ,CRP, puerperium disease, incision healing and economic index including costs and days of hospitalization among 3 groups. Result: The medincine index and average days of hospitali-zation had no statistics difference in 3 groups( P> 0. 05 ), but the costs had significant differences(P <0. 05 ). Conclusion: The single dose of ampicillin after umbilical cord was severed during operation have the same effection and others scheme in prevention of infection , but it can reduce the costs of hospitalization.%目的:探讨择期剖宫产术围术期抗生素应用的方案.方法:将择期剖宫产术围术期应用氨苄西林预防术后感染的产妇178例随机分为三组:A组50例术中断脐后立即静脉用药一次;B组70例术后立即及术后6h各静脉用药一次,2次;C组58例术后0.5h内首次给药,一天两次,术后48h内停药,4次.观察两组患者术后医学指标(术后发热率、术后血象异常升高率及CRP升高率、产褥病率、腹壁切口良好愈合情况)和经济学指标(住院费用及术后平均住院天数).结果:三组患者术后医学指标及术后平均住院天数无统计学差异(P>0.05),但住院费用的差异具有统计学意义(P<0.05).结论:择期剖宫产围术期应用氨苄西林在术中断脐后单次给药的短疗程预防术后感染临床效果好,是最佳给药时机及方案,可降低患者经济负担,操作简单,具有广泛临床推广价值的用药方案.
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