妊娠糖尿病孕妇糖化血红蛋白与甲状腺激素水平分析

摘要

Objective: To investigate the variations of glycosylated hemoglobin ( HbAlc ) and thyroid hormones and their clinical significance in gestational diabetes mellitus patients. Method: A number of 127 gestational diabetes mellitus patients were selected as case group, 179 normal pregnant women in the same period were randomly selected as control group. Triiodothyronine ( T3 ), thyroid hormones free triiodothyro-nine ( FT3 ), total thyroxine ( T4 ), free thyroxine ( FT4 ), thyroid stimulating hormone ( TSH ) and fasting blood sugar ( FBG ) were detected and correlation analysis were conducted between HbAlc and the above index. Result: The T3 ,FT3 ,T4 ,FT4 levels were significantly lower ( P<0. 05 ) in gestational diabetes mellitus patients, while HbAlc and FBG were significantly higher ( P<0.01 ) than those in normal pregnant women. HbAlc had a positive correlation with FBG ( r = 0. 44 ,P<0. 01 ), and a negative correlation with FT3( r= -0.29,P<0.05 ). Conclusion: HbAlc is a good index for monitoring the gestational diabetes condition, low levels of thyroid hormone are existed in diabetes mellitus patients.%目的:探讨妊娠糖尿病孕妇糖化血红蛋白(HbA1c)、甲状腺激素水平的变化及临床意义.方法:选择妊娠糖尿病孕妇127例为病例,随机选取同期正常妊娠妇女179例,测定三碘甲状腺原氨酸(T3)、游离三碘甲状腺原氨酸(FT3)、总甲状腺素(T4)、游离甲状腺素(FT4)、促甲状腺素(TSH)及空腹血糖(FBG)水平,并与HbA1c进行相关性分析.结果:与正常妊娠妇女相比,妊娠糖尿病孕妇的T3、FT3、T4、FT4水平明显下降,差异均有统计学意义(P<0.01);HbA1c与FBG明显上升(P<0.01);HbA1c与FBG呈正相关(r=0.44,P <0.01),与FT3呈负相关(r= -0.29,P <0.05).结论:HbA1c是监测妊娠糖尿病病情的良好指标,妊娠糖尿病孕妇存在甲状腺激素水平低下的现象.