缬沙坦对维持性血液透析患者微炎症和肺功能的影响探讨

摘要

Objective:To observe the influence of valsartan on micro-inflammation and lung function of patients with maintenance hemodialysis .Method:90 cases with maintenance hemodialysis were selected and divided into two groups randomly .Two groups received conventional maintenance hemodialysis , based on which the observation group was treated with valsartan .The micro-inflammation indicators and lung function indicators of two groups were monitored .Result:Before treatment, the micro-inflammation indicators inclu-ding CRP , IL-1, IL-6 and TNF-αand lung function indicators including FVC , FEV1 and MVV of two groups had no evident difference, which had no statistical significance (P>0.05).After treatment, the above indicators of the observation group were (5.22±0.76)mg/L, (177.68±19.32)ng/L, (87.73±10.06)ng/L, (4.72±0.43)ug/L, (2.27±0.31)L, (1.78±0.33) and (59.95±6.16)L, in which the micro-inflammation indicators were evidently lower than those of the control group , and the lung function indicators were evident-ly higher than that of the control group .The difference between two groups was evident , which had statistical significance ( P<0.05) .Conclusion:Adjuvant therapy of valsartan for patients with maintenance hemodialy-sis not only can effectively improve micro-inflammation state and lung function of patients , but also is easy , which is an easy and feasible treatment method .%目的：探讨缬沙坦对维持性血液透析患者微炎症和肺功能的影响。方法：选取维持性血液透析患者90例，随机分为两组，使其有可比性。两组患者均常规进行维持性血液透析，观察组患者在此基础上给予缬沙坦口服。对两组患者微炎症指标和肺功能指标进行监测。结果：两组患者治疗前CRP、IL-1、IL-6、 TNF-α各微炎症指标水平以及FVC、FEV1、MVV各肺功能指标水平差别不大，无统计学意义（P＞0．05）。经过治疗，观察组患者上述各指标分别为（5．22±0．76）mg/L、（177．68±19．32） ng/L、（87．73±10．06）ng/L、（4．72±0．43）ug/L、（2．27±0．31）L、（1．78±0．33）L和（59．95±6．16）L，其中微炎症各指标均明显低于对照组，肺功能各指标均明显高于对照组，两组比较差异明显，具有统计学意义（ P＜0．05）。结论：通过给予维持性血液透析患者缬沙坦辅助治疗，可以有效改善患者的微炎症状态和肺功能，且给药方便，是一种简单可行的治疗方法。