米氮平与舍曲林治疗阿尔茨海默病伴发的抑郁对照研究

摘要

目的：对比米氮平治疗阿尔茨海默病伴发的抑郁与舍曲林治疗的效果。方法：收集267例阿尔茨海默病伴发的抑郁患者随机分为3组，每组89例，分别为米氮平组、舍曲林组和安慰剂组，治疗周期为8周，采用康奈尔痴呆抑郁量表（CSDD量表）和Hamiltion抑郁量表（HAMD）评定临床效果。结果：舍曲林组、米氮平组与安慰剂组相比，治疗后2周的CSDD评分和HAMD评分差异均无统计学意义；治疗后4周和8周CSDD评分和HAMD评分较治疗前均有显著下降（ P＜0．05），两组间比较米氮平组CSDD评分和HAMD评分均较舍曲林组有显著差异（ P均＜0．05）。结论：米氮平治疗老年血管性痴呆伴抑郁有效，与舍曲林对比疗效相当，但副作用更少。%Objective:To evaluate the efficacy of mirtazapine and sertraline on depression Induced by alzheimer disease .Method:267 cases of elderly patients of dementia with depression in our hospital outpa-tient,they were randomly divided into three groups , the mirtazapine group (89 cases),sertraline group (89 cases)and control group (89 cases) for a period of eight weeks, using HAMD, CSDD rating scale to evalu-ate clinical effects .Result:There were significant difference between mirtazapine group ,sertraline group and control group HAMD and CSDD scores .Mirtazapine incidence of side effects , was higher than that of sertra-line group.Conclusion:It is suitable for the elderly patients that mirtazapine and sertraline have the equiva-lent therapeutic effects in the treatment of geriatric depression .