老年十二指肠溃疡根除Hp治疗对胃排空及炎症因子水平的影响

摘要

Objective: To study the influence of helicobacter pylori eradication treatment on gastric emptying and local inflammatory factors in old patients with duodenal ulcer. Methods:128 cases of old duode-nal ulcer were recruited from January 2014 to June 2015 and given helicobacter pylori eradication treatment in-cluding omeparazole (20mg Bid), amoxcilin (1.0g Bid), clarithromycin (500mg Bid), colloidal bismmth pectin (0.2g Tid) for 2 weeks and Omeparazole (20mg Bid) only for 2 weeks. Cases of successful helicobact-er pylori eradication as observation group and failed cases as control group, indexes of gastric emptying and lo-cal inflammatory factors were compared. Results:A successful helicobacter pylori eradication rate was 74.2%(95/128). Compared to failed helicobacter pylori eradication cases, the successful ones showed better im-provement in gastric emptying time, contraction frequency and amplitude of gastric antrum, gastroduodeal co-ordination( P <0.05) . While the failed ones also got better contraction frequency of gastric antrum compared to that before treatment( P<0.05) . Further study on inflammatory factors such as HSP60,VCAM,TNF-α,IL-6 of the observation group in gastric antrum resulted in lower level compared to that before treatment and after treatment of the control group (P <0.05). Conclusion: Successful helicobacter pylori eradication could im-prove gastric emptying,decrease local gastric inflammation.%目的：：研究老年十二指肠溃疡根除 Hp 治疗对胃排空及炎症因子水平的影响。方法：2014年1月至2015年6月收集老年消化性溃疡124例,进行四联Hp根除治疗[奥美拉唑(20mg 2次/d)、阿莫西林片(1.0g 2次/d)、克拉霉素(500mg 2次/d)、胶体果胶铋(0.23次/d)]2周,抑酸治疗(奥美拉唑20mg 2次/d)2周,治疗后Hp感染阴性作为观察组,Hp感染阳性为对照组,比较胃排空功能及炎症因子水平。结果：治疗后Hp感染根除率74.2％(95/128)。观察组老年十二指肠溃疡根除Hp治疗前胃排空时间、胃窦收缩频率、胃窦收缩幅度、胃十二指肠收缩协调性等指标与对照组相比较差异无统计学意义( P>0.05)；观察组治疗前后相比较T、F、F'差异具有统计学意义( P<0.05)；对照组治疗前后相比较胃窦收缩频率F差异具有统计学意义( P<0.05)；观察组、对照组治疗后相比较T、F、ΔA/A、F'差异具有统计学意义( P<0.05)。观察组老年十二指肠溃疡根除Hp治疗前HSP60、VCAM、TNF－α、IL－6等指标与对照组相比较差异无统计学意义( P>0.05)；观察组治疗前后相比较HSP60、VCAM、TNF－α、IL－6差异具有统计学意义(P<0.05)；对照组治疗前后相比较TNF－α、IL－6差异具有统计学意义(P<0.05)；观察组、对照组治疗后相比较HSP60、VCAM、TNF－α、IL－6差异具有统计学意义( P<0.05)。结论：老年性十二指肠溃疡根除Hp治疗能够改善胃排空功能,抑制局部炎症因子。