Objective To explore the risk factors of coronary artery disease (CHD) in different gender and the effect of gender on coronary stenosis severity. Methods Ninety-five patients who received angiography in our hospital from January 2008 to April 2010 were enrolled in the study. The correlation between age, smoking, hypertension, diabetes, stroke, blood lipid, the size of left atrium and ventricle, high sensitive C-reactive protein (hs-CRP) and CHD were analyzed in patients of different gender. CHD severity was evaluated by the number of coronaries with stenosis and the Gensini score. The relationship between gender and CHD severity was also analyzed. Results The differences in high density lipid protein cholesterol, hs-CRP and ventricle size were significant between the male CHD group and female CHD group. Gender was found to exert no effect on coronary stenosis severity. Conclusion Left ventricle dilation and high level of hs-CRP were independent predictors of CHD in males. High level of high density lipid protein cholesterol might protect the females from CHD. Gender itself does not contribute to the severity of coronary artery stenosis.%目的 探讨不同性别冠心病患者的危险因素及性别与冠脉病变程度的关系.方法 我院2008年1月至2010年4月行冠状动脉造影检查的患者95例,其中男性66例,女性29例.采用统计学方法对不同性别冠心病患者常见危险因素,如年龄、吸烟、高血压、糖尿病、脑梗塞、血脂水平、左房左室大小及高敏C反应蛋白等进行分析.通过冠脉病变支数及Gensini积分评估冠状动脉狭窄程度,同时探讨性别对冠脉病变程度的影响.结果 研究显示,高敏C反应蛋白(P=0.037)、高密度脂蛋白胆固醇水平(P=0.003)和左室大小(P=0.008)在不同性别的冠心病患者中差异具有统计学意义；不同性别间冠脉病变程度差异不具有统计学意义.结论 高敏C反应蛋白水平升高、左室扩大是男性冠心病患者的独立危险因素,而高水平的高密度脂蛋白胆固醇是女性冠心病患者的保护因素；性别本身并不影响冠脉病变严重程度.
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