目的：探讨分析乙肝疫苗联合免疫球蛋白在乙肝母婴传播途径阻断中的作用效果。方法选取从2010年1月至2012年11月在我院进行产前检查的住院分娩的200例HBsAg阳性孕妇及脐血为研究对象，所有孕妇的肝功能均正常。按照平均随机抽样的原则平均分为对照组和干预组，各为100例孕妇。对照组的新生儿在出生后24 h内接种乙肝疫苗联合免疫球蛋白100IU；干预组的孕妇在孕周为28、32和36周时，分别注射200IU的免疫球蛋白各1次，其新生儿在出生后的处理与对照组相同。所有病例均进行成功随访，观察接种后12个月两组新生儿乙肝五项检查情况。结果干预组和对照组的12个月新生儿HBsAg和HBsAb阳性率分别为1%、94%和6%、75%，两组间的差异均有有统计学意义（P＜0.05）。结论对新生儿肌内注射免疫球蛋白联合乙肝疫苗接种对乙肝母婴阻断中的作用效果显著，尤其是在分娩前进行免疫球蛋白产前干预具有良好的免疫阻断作用，降低了新生儿感染乙肝的概率安全有效，值得临床推广应用。%Objective To explore the analysis of the effects of hepatitis B vaccine combined with immunoglobulin blocking the route of transmission of hepatitis B maternal and child. Methods Select from January 2010 to November 2012 in our hospital for prenatal care , hospital delivery of 200 HBsAg-positive pregnant women and umbilical cord blood were Studies . ALL pregnant women were normal liver function . In accordance with the principle of random sampling average average divided into control and intervention groups, each of 100 cases of pregnant women. Control group of newborns within 24 hours after birth dose of hepatitis B vaccine combined immunoglobulin 100IU;intervention group of pregnant women in gestational age was 28, 32 and 36 weeks, were injected immunoglobulin 200IU of all time, their newborns after birth the same with the control group. All cases were successful follow-up , 12 months, three groups of neonatal hepatitis B five checks observed after vaccination.Results Intervention group and the control group 12 months newborns of HBsAg and HBsAb positive rate of 1%, 94%and 6%, 75%, the difference between the two groups were statistically significant (P<0.05).Conclusion Hepatitis B vaccine and immunoglobulin combined effect of vaccination of hepatitis B in the interruption of hepatitis B transmission from mother to child significantly , with good the immune blocking effect , reducing the chance of newborns infected with hepatitis B , safe and effective, worthy of clinical application.
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