二甲双胍治疗肥胖性2型糖尿病的临床分析

摘要

Objective Clinical analysis of metformin in treating typeⅡobese diabetes. Methods 100 patients were divided into two group randomly:control group (50 patients) and experimental group (50 patients). Experiment group were treated combine metformin(500mg each times, twice a day) and insulin human (object before breakfast and dinner);Control groups were treated with insulin (object before breakfast and dinner). Indexes like FPG、2hPG、TC、TG、HDL-C、LCL-C、HbA1c、BMI were detected before and 18 weeks after treatment. Results After treatment ,index like FPG、2hPG、HbA1c、TG、LDL-C were declined significant (P<0.05). Compared with control group , index like TG、LDL-C和BMI in experiment group were declined significant (P<0.05). Conclusion Blood lipid levels and BMI of typeⅡobese diabetes can be obviously improved by metformin.%目的：研究二甲双胍对肥胖性糖尿病治疗的临床分析。方法肥胖性2型糖尿病患者100例，随机分为实验组和对照组各为50例。实验组给与二甲双胍500毫克/次，1天2次，同时早晚餐前注射人胰岛素，对照组早晚餐前注射人胰岛素。两组患者在治疗前和18周治疗后均检测空腹血糖（FPG），餐后2 h血糖（2hPG），血脂（TC、TG、HDL-C、LDL-C），糖化血红蛋白（HbA1c）及体指数（BMI）等相关指标。结果两组患者血清FPG、2hPG、HbA1c、TG、LDL-C水平与治疗前比较均明显降低（P＜0.05）。同时，实验组与对照组比较，患者血清TG、LDL-C和BMI均明显降低（P＜0.05）。结论二甲双胍能明显改善肥胖2型糖尿病患者血脂水平和体质量指数。