脾切除与肝移植治疗门静脉高压症的相关研究

摘要

肝移植目前被认为是治疗门静脉高压症的最有效措施，脾切除是治疗肝硬化合并上消化道出血患者的有效方法。早期报导认为，脾切除可减少抗体的产生，降低排斥反应发生率，并且治疗肝移植术后持续性血小板减少症。近年来，不断有报导提出脾切除可增加肝移植患者术后的感染率、病死率及动静脉血栓形成的危险性。脾切除对肝移植患者的影响，目前尚未见详细报道。%Liver transplantation is considered to be the most effective measures for the treatment of portal hypertension(PHT) at present. Splenectomy is a effective treatment for patients with hepatocirrhosis with upper gastrointestinal bleeding. Early reports that splenectomy can decrease the production of antibodies, reduce rejection rate, and treat persistent thrombocytopenia after liver transplantation. In recent years, there have been reports suggested splenectomy can increase the liver transplantation in patients with postoperative infection rate, mortality and the risk of venous thrombosis. The effect of splenectomy in patients with liver transplantation, has yet to see the detailed report.