3-甲基-1-戊烯-4-炔-3-醇的合成研究进展

摘要

3-甲基-1-戊烯-4-炔-3-醇在类胡萝卜素的合成中是重要的中间体之一，随着市场对类胡萝卜素需求的日益增长，关于3-甲基-1-戊烯-4-炔-3-醇的合成不断有新方法报道。在该文中根据引入乙炔基的不同方法，通过四类不同的乙炔化方法，简述3-甲基-1-戊烯-4-炔-3-醇的合成优缺点，比较各种不同合成方法间实现工业化生产的可能性，为其进一步研究与应用提供参考。%3-methyl-1-pentene-4-yn-3-ol is one of the significant intermediates in the synthesis of carotenoids. With the growing market demand for carotenoids, the new synthesis methods of 3-methyl-1-pentene-4-yn-3-ol were reported continuously. According to different means for introducing acetenyl, the advantages and disadvantages in synthesis of 3-methyl-1-pentene-4-yn-3-ol via four different kinds of ethinylation were sketched. The possibility of realizing the industrialization production of various synthetic methods was compared. This provided the reference for the further study and application.