布地奈德雾化吸入佐治老年支气管哮喘的临床疗效研究

摘要

目的 探讨老年支气管哮喘的治疗方法.方法 选择90例老年支气管哮喘急性发作期患者随机分为布地奈德佐治组(试验组)和常规治疗组(对照组),每组各45例.对照组患者接受常规治疗;试验组患者在常规治疗基础上加用布地奈德雾化吸入,共2 w.分别检测两组患者的疗效、临床症状与体征消失时间、第一秒用力呼气容积/用力呼气量预计值的百分比( FEV1％)、第一秒用力呼气容积/用力肺活量百分比(FEV1/FVC％)、最大呼气峰值流速实测值占预计值的百分比(PEF％),并进行比较与统计学分析.结果 布地奈德佐治组的总有效率显著高于常规治疗组(84.44％ vs.73.33％,P＜0.05),咳嗽、喘息、胸闷、肺哮鸣音等症状、体征消失时间明显少于常规治疗组(均P＜0.01、P＜0.05).各组治疗前后比较,治疗后FEV1％、FEV1/FVC％和PEF％均显著升高(P＜0.01);与常规治疗组治疗后比较,布地奈德佐治组治疗后的FEV1％、FEV1/FVC％和PEF预计值均明显升高,差异有统计学意义(P＜0.01).结论 布地奈德对老年支气管哮喘有很好的辅助疗效.%Objective To study the clinical outcome of budesonide via aerosol inhalation on acute exacerbation of bronchial asthma in the elderly patients. Methods 90 elderly cases with acute exacerbation of bronchial asthma were randomly divided into conventional therapy group (control group, n =45) and convention pluse budesonide therapy group (experimental group, n=A5). The efficacy, clinical symptoms and signs disappeared time and the levels of FEV1%, FEV1/FVC%, PEF % in the two groups were compared and statistically analyzed. Results The total efficient rate of the experimental group was higher than that of the conventional therapy group (84.44% vs. 73.33%, P<0.05). The disappeared time of wheezing, coughing, chest tightness and pulmonary wheezing sound in the experimental group were shorter than those of the control group (P<0.01, 0.05). Conclusion Budesonide has good assisted treatment effect on bronchial asthma in the elderly patients.