采用喷雾干燥技术制备中链甘油三酯微胶囊,将中链甘油三酯固态化,方便食品添加和储运;以人工胃液模拟体外释放,初步研究了中链甘油三酯微胶囊的缓释特性;并以基础合成饲料、长链甘油三酯微胶囊高脂饲料（长链甘油三酯供能占总能量30%左右）和中链甘油三酯微胶囊高脂饲料（中链甘油三酯供能占总能量30%左右）分别饲喂小鼠,并观察5周内小鼠健康状况和体质量、血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）含量、低密度脂蛋白胆固醇（LDL-C）含量、饲料消耗量的变化,研究中链甘油三酯对小鼠脂质代谢的影响。结果表明,中链甘油三酯微胶囊在人工胃液中可缓慢释放6h,能够缓解中链甘油三酯一次性摄入量超标引起的腹痛腹泻问题,膳食中添加中链甘油三酯微胶囊后,能降低体内TC和LDL-C的含量,中链甘油三酯微胶囊的高脂膳食具有预防肥胖、减少体质量增长和体脂累积、减轻肝脏脂肪沉积的作用,且其抑制体质量增长的机制与减少能量摄入量无关。%Medium-chain triglycerides（MCTs） were microencapsulated by spray-drying method with the purpose of solidification,which makes it convenient to add and store MCTs.In the present study,artificial gastric fluid was used to preliminarily investigate release characteristics in vitro of MCT microcapsules.Net basic synthetic diet,long-chain triglyceride（LCT） microcapsule-supplemented diet（the energy of LCTs accounting for about 30% of total energy） and MCT microcapsule-supplemented diet（（the energy of MCTs accounting for about 30% of total energy） were separately used to feed mice for 5 consecutive weeks.The changes in health status,body weight,the levels of serum triglyceride（TG）,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C） and food intake of mice were observed during the period to understand the effect of MCT microcapsules on lipid metabolism in mice.The results showed that the release of MCT microcapsules in artificial gastric fluid could last 6 h so that abdominal pain and diarrhea caused by excessive intake of MCTs at one time could be relieved.The contents of TC and LDL-C in mice were reduced by supplementing MCT microcapsules in basic synthetic diet and meanwhile,the functions to prevent obesity,reduce body weight gain and fat accumulation and attenuate fat deposition in the liver.Furthermore,the mechanisms of inhibition of body weight gain were independent on reduced energy intake.
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