急性白血病合并DIC时联合检测CRP及D-D的临床价值探讨

摘要

目的：探讨急性白血病合并DIC时联合检测CRP及D-D的临床价值。方法选取从2013年3月至2016年1月，于福建医科大学附属三明第一医院进行治疗的AL病患72例，其中合并DIC病患36例为观察组，单纯AL病患36例为对照组。两组病患均进行静脉血CRP及D-D含量检测，并对结果进行统计分析。结果观察组CRP和D-D含量均显著高于对照组；CRP含量≥100mg/L病患的D-D水平以及DIC发生率均显著高于CPR含量在10～100mg/L的病患；采用CRP、D-D检测灵敏度、特异性以及准确度对比无显著差异，但采用CRP联合D-D检测得到的灵敏度、特异性以及准确度均显著高于CRP、D-D检测结果，差异均有统计学意义（均P＜0.05）。结论联合检测CRP及D-D能有效预测AL病患DIC的发生，具有极其重要的临床意义。%Objective To study the clinical value of combined detection of CRP and D-D in acute leukemia (AL) with dissem-inated intravascular coagulation (DIC). Methods Seventy-two cases of AL patients treated in the Sanming First Hospital Affiliated to Fujian Medical University between March 2013 to January 2016 were collected,including 36 cases of DIC patients as the obser-vation group,36 cases of simple AL patients as the control group. The serum CRP and D-D levels of all participants were mea-sured,and the results were statistically analyzed. Results The levels of CRP and D-D in the observation group were significantly higher than that in the control group;the levels of DD and the incidence of DIC in patients whose the CRP levels were more than 100mg/L were significantly higher than those whose CPR concentrations were 10~100mg/L;There were no significant differences in sensitivity,specificity and accuracy when used CRP or D-D only in two groups,but the sensitivity,specificity and accuracy in were significantly higher when CRP combined with D-D detection (all P<0.05). Conclusion The combined detection of CRP and D-D can effectively predict the occurrence of AL combined with DIC,which has a very important clinical significance.