OBJECTIVE:To investigate the application status and change trend of outpatient antidepressants in the Second Affiliated Hospital of Xinxiang Medical University ( hereinafter referred to as "our hospital") during 2013-2016, so as to provide reference for the rational drug application in clinic. METHODS:Medication frequence method was adopted, statistically retrospective analysis was conducted on the application data of consumption sum, defined daily dose system (DDDs) and defined daily cost (DDC), etc. RESULTS: The outpatient antidepressants in our hospital was in an increasing trend during 2013-2016 , the consumption sum of 2013 increased from 14. 9339 million yuan to 18. 9842 million yuan in 2014 , with the increasing rate of 27. 12％ and annual increasing rate of 6. 78％. The most frequently used antidepressants of our hospital were respectively sertraline, mirtazapine, escitalopram, paroxetine and venlafaxine. The consumption sum and DDDs of selective serotonin reuptake inhibitors ( SSRI ) and selective serotonin and norepinephrine reuptake inhibitors(SNRI) showed a increasing trend, yet the application of tricyclic antidepressants was reducing year by year. CONCLUSIONS: The consumption sum and DDDs of antidepressants showed increasing trend in clinical treatment. Meanwhile, SSRI, selective serotonin and SNRI have become the first-line antidepressants in clinical application.%目的:了解2013—2016年新乡医学院第二附属医院(以下简称"我院")门诊抗抑郁药使用情况及变化趋势,为合理用药提供参考.方法:采用限定日剂量法,对2013—2016年我院门诊抗抑郁药的销售金额、用药频度、限定日费用等进行回顾性统计分析.结果:2013—2016年我院门诊抗抑郁药的销售金额逐年上升,由2013年的1493.39万元增至2016年的1898.42万元,增长了27.12％,年均增长率为6.78％;舍曲林、米氮平、艾司西酞普兰、文拉法辛、帕罗西汀等为最常用药物;选择性5-羟色胺再摄取抑制剂、选择性5-羟色胺和去甲肾上腺素再摄取抑制剂的销售金额及用药频度逐年增长,而经典三环类抗抑郁药则逐年减少.结论:我院新型抗抑郁药的销售金额和DDDs呈上升趋势,选择性5-羟色胺再摄取抑制剂、选择性5-羟色胺和去甲肾上腺素再摄取抑制剂已成为一线抗抑郁药.
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