School of Food Science and Engineering University 570228;
Department of Pediatrics of California San Diego Jolla 92093;
Center for Microbiome Innovation School of Engineering of California San Diego Jolla 92093;
Department of Bioengineering of California San Diego Jolla 92093;
Department of Computer Science and Engineering of California San Diego Jolla 92093;
Gut microbiota; Genomic mutations; Adaptive evolution; Purifying selection; Single-nucleoti de variants;