ROLES OF SPINAL PROTEIN KINASES IN BEE VENOM-INDUCED PERSISTENT SPONTANEOUS NOCICEPTION AND HYPERALGESIA

摘要

Aim: It has been shown that spinal protein kinases (Pigs) such as PKC and PKA may play important roles in induction or maintenance of persistent nociception and hyperagesia. In the present study, we examined the spinal roles of PKC and cAMP-dependent PKA in development and maintenance of the bee venom(BV)-induced persistent spontaneous nociception and hyperalgesia in conscious rats with chronically intrathecal catheterization.