首页> 中文期刊> 《当代医学科学(英文)》 >Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics

Changes of Serum Insulin-like Growth Factor-2 Response to Negative Symptom Improvements in Schizophrenia Patients Treated with Atypical Antipsychotics

         

摘要

Accumulating evidence suggests that a disruption of early brain development,in which insulin-like growth factor-2(IGF-2)has a crucial role,may underlie the pathophysiology of schizophrenia.Our previous study has shown that decreased serum IGF-2 was correlated with the severity of psychopathology in patients with schizophrenia.Here we conducted a prospective observation trial to investigate the effects of atypical antipsychotics on serum IGF-2 level and its relationship with clinical improvements in schizophrenia patients.Thirty-one schizophrenia patients with acute exacerbation and 30 healthy individuals were recruited in this study.Psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale(PANSS)and serum IGF-2 levels were determined using ELISA.We found that schizophrenia patients with acute exacerbation had lower serum IGF-2 levels than control individuals at baseline(P<0.05).After 2 months of atypical antipsychotic treatment,a significant improvement in each PANSS subscore and total score was observed in patients(all P<0.01),and the serum IGF-2 levels of patients were significantly increased compared with those at baseline(203.13±64.62 vs.426.99±124.26 ng/mL;t=−5.044,P<0.001).Correlation analysis revealed that the changes of serum IGF-2 levels in patients were significantly correlated with the improvements of negative symptoms(r=−0.522,P=0.006).Collectively,our findings demonstrated changes of serum IGF-2 response to improvements of negative symptoms in schizophrenia patients treated with atypical antipsychotics,suggesting that serum IGF-2 might be a treatment biomarker for schizophrenia.

著录项

  • 来源
    《当代医学科学(英文)》 |2020年第3期|P.563-569|共7页
  • 作者单位

    Department of Psychosomatic Medicine The First Affiliated Hospital of Nanchang University Nanchang 330006 China;

    Biological Psychiatry Laboratory Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University Nanchang 330029 China;

    Department of Psychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University Nanchang 330029 China;

    Biological Psychiatry Laboratory Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University Nanchang 330029 China;

    Biological Psychiatry Laboratory Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University Nanchang 330029 ChinaDepartment of Psychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University Nanchang 330029 China;

    Department of Neurology The Second Clinical Medical College The Second Affiliated Hospital Fujian Medical University Quanzhou 362000 China;

    Biological Psychiatry Laboratory Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University Nanchang 330029 ChinaDepartment of Psychiatry Jiangxi Mental Hospital/Affiliated Mental Hospital of Nanchang University Nanchang 330029 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    schizophrenia; atypical antipsychotic; insulin-like growth factor-2; negative symptoms;

    机译:精神分裂症;非典型抗精神病药;胰岛素样生长因子2;阴性症状;
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