2型糖尿病合并早期糖尿病肾病的相关危险因素分析

摘要

Objective To explore the related risk factors of type 2 diabetic patients with early diabetic nephropathy. Methods Totally 183 type 2 diabetes mellitus patients were enrolled, they were randomly divided into simple diabetes mellitus group(SDM group,UAER<20μg/min)and early diabetic nephropathy group(EDN group,UAER 20-200μg/min)according to the urinary protein excretion rate(UAER). Analyze the relevance of the related factors of the two groups. Results(1)Single factor analysis:The course of disease(t=5.56)、BMI(t=3.05)、HDL-C(t=7.25),LDL-C (t=11.36),HbA 1 c(t=14.12)are signiifcantly different between SDM group and EDN group(P<0.05);(2) There were 4 factors entered last regression model according to mulitiple factor analysis. They were the course of disease(OR=1.110,95%CI 1.033~1.178), BMI(OR=1.103,95%CI 1.023~1.324), HDL-C(OR=1.203,95%CI 1.027~1.279)and LDL-C(OR=1.873,95%CI 1.194~3.210).Conclusion Course of the disease, obesity, high blood lipids are the risk factors of type 2 diabetic patients with early diabetic nephropathy. A series of comprehensive measures should be taken early to prevent and control the related risk factors.%　　目的探讨2型糖尿病合并早期糖尿病肾病患者的相关危险因素。方法对183例2型糖尿病患者病历回顾性分析，按照患者尿白蛋白排泄率（UAER）水平分为单纯糖尿病组（SDM组，UAER<20μg/min）与早期糖尿病肾病组（EDN组，UAER 20～200μg/min），并对两组相关因素进行分析比较。结果（1）SDM组与EDN组各指标的单因素分析中，患者病程（t=5.56）、BMI（t=3.05）、HDL-C（t=7.25）、LDL-C（t=11.36）、HbA 1 c（t=14.12）有统计学意义（P<0.05）；（2）Logistic多因素分析中则有四个因素进入多因素回归模型，分别为病程（OR=1.110，95%CI 1.033～1.178）、BMI（OR=1.103，95%CI 1.023～1.324）、HDL-C（OR=1.203，95%CI 1.027～1.279）及LDL-C（OR=1.873，95%CI 1.194～3.210）。结论病程、肥胖、高血脂是2型糖尿病合并早期糖尿病肾病患者危险因素，应早期针对相关危险因素进行防治。