Objective To investigate the clinical efficacy of ambroxol hydrochloride on the treatment of chronic obstructive pulmonary disease with acute exacerbation. Methods 126 cases of chronic obstructive pulmonary disease with acute exacerbation were divided into the observation group and the control group, each with 63 cases. The control group was treated with the symptomatic and supportive treatment for anti-infection, spasmolysis, asthma relief and cough relief. The observation group was treated with ambroxol hydrochloride additionally. Dosage:30 mg ambroxol hydrochlorid was dissolved into 100 mL 0.9%sodium chloride injection for intravenous drip, twice each day and 14 days for each treatment course. Observations were carried out about the pulmonary function improvement of both groups with efficacy appraisal. Results After treatment, the VC max, FEV 1, FEV 1/FVC, MMEF, PEF of the patients in observation group were (2.56±0.41)mL, (1.49±0.41)L, (69.82±22.15), (1.46±0.42)mL/s, (4.36±1.29)L/min, much better than (2.31±0.39)mL, (1.32±0.40)L, (52.18±16.51), (1.31±0.41)mL/s, (3.30±1.39)L/min of the control group (P<0.05). The overall response rate of the patients in observation group was 98.41%, while the overall response rate of the control group was 77.78%. The difference was statistically significant (P<0.05). Conclusion Treatment of chronic obstructive pulmonary disease with acute exacerbation with ambroxol hydrochloride besides the conventional therapy can improve the pulmonary function and the overall efficacy.%目的：探讨盐酸氨溴索治疗急性发作期慢性阻塞性肺疾病的临床疗效。方法将126例慢性阻塞性肺疾病急性发作期患者均分为观察组和对照组（n=63）。对照组给予抗感染、解痉、平喘、止咳等对症支持治疗，观察组在此基础上加用盐酸氨溴索治疗，剂量：将盐酸氨溴索30 mg溶于0.9%氯化钠注射液100 mL中静脉滴注，2次/d。2组疗程均为14 d，观察2组患者肺功能改善情况，并进行疗效评定。结果观察组患者治疗后VC max、FEV 1、FEV 1/FVC、MMEF、PEF分别为(2.56±0.41)mL、(1.49±0.41)L、(69.82±22.15)、(1.46±0.42)mL/s、(4.36±1.29)L/min，明显优于对照组的(2.31±0.39)mL、(1.32±0.40)L、(52.18±16.51)、(1.31±0.41)mL/s、(3.30±1.39) L/min（P＜0.05）；观察组患者治疗总有效率为98.41%，显著高于对照组的77.78%，差异有统计学意义（P＜0.05）。结论在常规治疗的基础上加用盐酸氨溴索治疗急性发作期慢性阻塞性肺疾病，可在改善肺功能的同时提高总体治疗效果。
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